Broadening Genetic Testing for Parkinson's Disease Patients

A study in the medical journal Brain found higher-than-expected genetic mutations in Parkinson's disease patients, suggesting broader genetic testing. Analysis of over 8,000 patients revealed significant genetic links, urging genetic testing for everyone with Parkinson’s, especially with new gene-specific treatments under development.

New research indicates that a higher-than-expected prevalence of gene mutations among Parkinson's disease patients necessitates broader genetic testing. Published in the medical journal Brain, the study's authors recommend genetic profiling for all Parkinson's patients, given that 13% showed genetic forms of the disorder.

The analysis covered over 8,000 patients of diverse races and ethnicities, revealing a genetic basis in 18% of those with known risk factors such as early onset or family history. Surprisingly, even in patients without these factors, 9% carried predisposing mutations.

James Beck of the Parkinson's Foundation emphasized that advances in gene-specific treatments could revolutionize patient care. With trials underway, comprehensive genetic testing may help refine prognosis and familial risk assessment. The PDGENE study offers free genetic testing to all Parkinson's patients.

(With inputs from agencies.)