Unlocking Longevity: The Gut Hormone Connection

A study from Brown University explores how a gut hormone in fruit flies may control lifespan. The research highlights the insulin-regulating neuropeptide F hormone's role in extending longevity, relevant to humans due to similar genetic and hormonal traits. Understanding these mechanisms could influence treatments for ageing-related conditions.

Researchers at Brown University have uncovered a potential key to longevity through a study on fruit flies. The findings suggest that a gut hormone, neuropeptide F, which is involved in regulating insulin, could be instrumental in controlling the lifespan of these insects. Importantly, this research may hold implications for humans, given the genetic and hormonal similarities between the two species.

The study demonstrated that by suppressing the activity of neuropeptide F in the intestines, fruit flies experienced extended longevity. This was achieved by reducing insulin levels and manipulating gene activity associated with juvenile hormone production. These results offer insights into the complex mechanisms of ageing that may translate to human conditions.

Given the rise of diabetes and obesity drugs targeting similar hormonal pathways, understanding the relationship between insulin regulation and ageing could have significant implications. As the study suggests, these drugs might affect human ageing processes, highlighting a need for further investigation. The research, published in the Proceedings of the National Academy of Sciences, underscores the gut's vital role in ageing science.

(With inputs from agencies.)