Diet's Role in MS: Uncovering the C16 Ceramide Connection

A study led by Patrizia Casaccia reveals how enzymes CerS5 and CerS6 cause palm oil to worsen MS symptoms. The research highlights the impact of diet on MS progression, suggesting enzyme targeting as a strategy for neuroprotection.

Groundbreaking research spearheaded by Patrizia Casaccia, a prominent figure in neuroscience at CUNY Graduate Center, has identified how certain enzymes escalate the severity of multiple sclerosis (MS) symptoms due to a palm-oil-rich diet. The study underscores the pivotal role of enzymes CerS5 and CerS6 in converting palm oil into a toxic compound that aggravates neurodegeneration.

Using the experimental autoimmune encephalomyelitis model, the researchers found high palm oil consumption to increase MS severity in mice. "Within neuronal cells, palm oil is transformed into C16 ceramide by CerS5 and CerS6, leading to mitochondrial damage," explained Casaccia, pointing out the resultant energy deprivation in neurons.

Remarkably, removing these enzymes genetically in neurons halted neurodegeneration, even in mice consuming palmitic acid-rich diets. This crucial discovery hints at a specific metabolic pathway where dietary fats exacerbate MS symptoms. The findings can influence MS management strategies by highlighting the importance of dietary choices and identifying enzyme-targeted therapeutic approaches.

(With inputs from agencies.)